Male Hormone Panel

Hormone imbalance affects men too - in fact, low testosterone is a common cause of irritability and grumpiness in men. If too much testosterone is converted to estradiol, decreased sex drive and increased breast size can result.

Saliva hormone testing is simple, accurate, and easily obtained. Four hormones make up the Male Panel: cortisol, DHEAs, estradiol, and testosterone.  Interactions between these hormones are fundamental to health - which is why imbalances can have a significant impact on well-being.

Other conditions associated with male hormone imbalance:

  • Apathy, depression
  • Bone loss
  • Erectile dysfunction
  • Memory loss
  • Weight gain
  • Benign prostate hyperplasia (enlarged prostate)

Why Order a Male Hormone Panel?

Men who experience symptoms like those above that are not relieved by mainstream medical interventions, may benefit from having a saliva hormone test. Knowing your hormone levels and how hormones work together may help your clinician find the right hormone solution for you. 

Common hormone concerns:

Interactions between the four hormones of the male panel (see right) are fundamental to health, which means that hormone imbalance may have a negative effect on health. The following are examples of how hormone imbalance can affect health:

Bone Loss

Testosterone and estradiol help build bone, while high cortisol tends to break down bone. High cortisol is of particular concern because it interferes with the bone-building action of testosterone.

Erectile Dysfunction

Testosterone receptors are plentiful in the brain, so a lack of testosterone may result in decreased arousal response. Testosterone is also needed for muscle contraction, so low testosterone may result in poor erection quality. Low testosterone may also lead to increased ‘wait’ times between erections.

Memory Loss

Because testosterone receptors are abundant in the brain, low testosterone levels often affect memory.

Apathy, Depression, Grumpiness

Our laboratory data shows that approximately 3/5 of men with self-reported symptoms including aggression, apathy, depression, irritability and an inability to cope have at least one out-of-range hormone result. This is not proof that restoring hormone balance will lessen these mood symptoms, but many men experience some relief from mood disorders when hormone balance is restored.

Breast Enlargement

Men who carry extra weight around the middle have more of the enzyme aromatase, which converts testosterone to estrogen. Increased estrogen can lead to breast enlargement.

Weight Gain

High levels of the stress hormone cortisol can cause unstable blood sugar levels and may increase sugar cravings.

Benign Prostatic Hyperplasia (BPH)

Most men over the age of 60 have signs of prostate enlargement, also known as BPH. Some researchers have suggested that low testosterone and/or high estradiol may be contributing factors in prostate enlargement.

The Hormones tested in this panel:

  • Helps maintain muscle mass and bone, improves sense of well-being, helps control blood sugar, is needed for heart health, and improves sex drive.
  • Responsible for male sex characteristics like facial and body hair growth, deepening of voice, and development of male sex organs.
  • The testes produce approximately 20% of a man’s estradiol, while the rest is converted from estosterone via the enzyme aromatase (found in fat cells).
  • Estrogens can compete with testosterone for receptor sites, which means that having too much estradiol may reduce the effect of testosterone.
  • This major stress hormone is released by the adrenal glands.
  • High or low cortisol levels may be an indication of poor adrenal function.
  • DHEA is an adrenal hormone that circulates in blood primarily as DHEA sulfate (DHEAS).
  • DHEA and cortisol have opposite effects on immune function and blood glucose control.

Why do we use saliva to test hormones?

  • Saliva testing measures the free, biologically active hormone levels - hormones that actually make it into tissue, because hormones pass through saliva gland tissue before getting into saliva.
  • Saliva hormone testing offers fast, reliable and accurate way of assessing hormone levels, The simplicity of saliva collection in the home makes it ideal for mapping out hormone levels over a complete menstrual cycle.
  • It is impractical to collect blood every three days to map out estradiol and progesterone over a complete menstrual cycle, nor could an average for testosterone, cortisol and DHEAS be provided.
  • The stress of a needle puncture for blood collection tends to raise cortisol levels.

Male hormone balance:


Low testosterone levels do not necessarily mean you need to supplement with testosterone. Your healthcare professional may want to investigate options like zinc supplementation, which can slow the conversion of testosterone into estradiol. If these or other interventions do not relieve low testosterone symptoms, likely only then will your healthcare professional consider supplementing with testosterone.

High testosterone is generally a consequence of supplementing with too much testosterone. Although naturally high levels are rarely a problem, significantly elevated testosterone may require a referral to a medical specialist.


Low estradiol levels are rarely a problem for men. However, if estrogen levels are low and symptoms of low estrogen are present, supplements may help. For example, boron may help boost estrogen production, while plant estrogens and progesterone may relieve symptoms of low estrogen.

High estradiol levels in men generally occur as a result of conversion from testosterone. An enzyme called aromatase changes testosterone into estradiol. Aromatase lives in the fat cells, so men who carry extra weight around the middle tend to have more cortisol and consequently make more estradiol. Cortisol increases the activity of the aromatase enzyme, so high cortisol levels can also lead more testosterone to be converted into estradiol.

Thus, weight loss and stress reduction are important steps in restoring the balance of hormones.


Low cortisol in the morning may be indicative of adrenal issues, which may require further testing or interventions by your healthcare professional.

High cortisol levels are associated with numerous symptoms and conditions including: bone loss, high blood pressure, insulin resistance and diabetes, weight gain, memory impairment and immune system suppression. High cortisol levels also interfere with the action of other hormones. Therefore, when cortisol levels are high, the first step in restoring hormone balance should be to reduce high cortisol levels. Your healthcare professional may recommend lifestyle changes as well as supplements to help address high cortisol levels.


Low DHEAs symptoms are not well-defined although low DHEAs is often associated with chronic illness. Some men benefit from supplementing with DHEA to bring saliva hormone levels back within range.

High DHEAs may be a consequence of supplementing with too much DHEA, in which case your health care provider may recommend reducing the dose.


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